製品の概要

  • 製品名Anti-SH3KBP1 antibody
    SH3KBP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SH3KBP1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 144-193 (TGMFPSNFIK ELSGESDELG ISQDEQLSKS SLRETTGSES DGGDSSSTKS) of Human SH3KBP1 (NP_001019837)

  • ポジティブ・コントロール
    • Jurkat cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab104295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
  • 組織特異性Ubiquitously expressed. Also expressed in some cancer cell lines.
  • 配列類似性Contains 3 SH3 domains.
  • ドメインThe SH3 domains mediate interaction with SHKBP1.
  • 翻訳後修飾Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
  • 細胞内局在Cytoplasm > cytoskeleton. Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome. Cell junction > focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • c Cbl interacting protein antibody
    • Cbl interacting protein antibody
    • Cbl interacting protein of 85 kDa antibody
    • Cbl-interacting protein of 85 kDa antibody
    • CD2 binding protein 3 antibody
    • CD2-binding protein 3 antibody
    • CD2BP3 antibody
    • CIN 85 antibody
    • CIN85 antibody
    • GIG 10 antibody
    • GIG10 antibody
    • HSB 1 antibody
    • HSB-1 antibody
    • HSB1 antibody
    • Human Src family kinase binding protein 1 antibody
    • Human Src family kinase-binding protein 1 antibody
    • MIG 18 antibody
    • MIG18 antibody
    • Migration inducing gene 18 antibody
    • Migration inducing gene 18 protein antibody
    • SH3 domain kinase binding protein 1 antibody
    • SH3 domain-containing kinase-binding protein 1 antibody
    • SH3BP 1 antibody
    • SH3K1_HUMAN antibody
    • SH3KBP1 antibody
    • Src family kinase binding protein 1 antibody
    • src related kinase binding protein 1 antibody
    see all

Anti-SH3KBP1 antibody 画像

  • Anti-SH3KBP1 antibody (ab104295) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 73 kDa

Anti-SH3KBP1 antibody (ab104295) 使用論文

ab104295 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"