製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SH3BP2
  • アプリケーション
    適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 400-450 of Human SH3BP2 (NP_001116153.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH: 7-8
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab117833 was affinity purified using an epitope specific to SH3BP2 immobilized on solid support.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab117833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-10 µg/mg of lysate.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
    • 組織特異性
      Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
    • 関連疾患
      Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
    • 配列類似性
      Contains 1 PH domain.
      Contains 1 SH2 domain.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 3BP-2 antibody
      • 3BP2 antibody
      • 3BP2_HUMAN antibody
      • Abl SH3 binding protein 2 antibody
      • Cherubism antibody
      • CRBM antibody
      • CRPM antibody
      • FLJ42079 antibody
      • FLJ54978 antibody
      • RES4-23 antibody
      • SH3 domain binding protein 2 antibody
      • SH3 domain-binding protein 2 antibody
      • Sh3bp2 antibody
      • TNFAIP3 interacting protein 2 antibody
      see all

    画像

    • Detection of Human SH3BP2 by Immunoprecipitation of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab117833 at 6 µg/mg of lysate. Subsequent WB detection was done using an other anti Human SH3BP2 antibody.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    プロトコール

    参考文献

    ab117833 has not yet been referenced specifically in any publications.

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