製品の概要

  • 製品名Anti-SGCE antibody
    SGCE 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SGCE
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (TVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDP I) of human SGCE (NP_001092871).

  • ポジティブ・コントロール
    • 721_B cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 組織特異性Ubiquitous.
  • 関連疾患Defects in SGCE are a cause of dystonia type 11 (DYT11) [MIM:159900]; also known as myoclonic dystonia or alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • 配列類似性Belongs to the sarcoglycan alpha/epsilon family.
  • 細胞内局在Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 参照データベース
  • 別名
    • dystonia 11, myoclonic antibody
    • DYT11 antibody
    • Epsilon sarcoglycan antibody
    • Epsilon SG antibody
    • Epsilon-sarcoglycan antibody
    • Epsilon-SG antibody
    • ESG antibody
    • sarcoglycan, epsilon antibody
    • sgcE antibody
    • SGCE_HUMAN antibody
    see all

Anti-SGCE antibody 画像

  • Immunohistochemistry with pFA fixed Human skeletal muscle tissue at an antibody concentration of 5.0ug/ml using anti-SGCE antibody (ab84660)
  • ab84660 at a 1/500 dilution staining SGCE in Mouse cerebellum tissue by Immunohistochemistry.

  • Anti-SGCE antibody (ab84660) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 50 kDa
    Observed band size : 50 kDa

Anti-SGCE antibody (ab84660) 使用論文

ab84660 has not yet been referenced specifically in any publications.

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