製品の概要

  • 製品名Anti-SFRP4 antibody
    SFRP4 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to SFRP4
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Pig
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human SFRP4.

  • ポジティブ・コントロール
    • Human Skeletal Muscle (Interstitial Cells) tissue; Human uterus lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab122905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
IHC-P Use a concentration of 3.75 µg/ml.

ターゲット情報

  • 機能Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
  • 組織特異性Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
  • 配列類似性Belongs to the secreted frizzled-related protein (sFRP) family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 NTR domain.
  • ドメインThe FZ domain is involved in binding with Wnt ligands.
  • 細胞内局在Secreted. Cytoplasmic in ovarian tumor cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Frizzled protein antibody
    • Frizzled protein human endometrium antibody
    • FRP 4 antibody
    • FRP4 antibody
    • FrpHE antibody
    • human endometrium antibody
    • Secreted frizzled-related protein 4 antibody
    • sFRP-4 antibody
    • Sfrp4 antibody
    • SFRP4_HUMAN antibody
    see all

Anti-SFRP4 antibody 画像

  • ab122905, at 3.75 µg/ml, staining SFRP4 in Formalin-fixed, Paraffin-embedded Human Skeletal Muscle (interstitial cells) tissue by Immunohistochemistry.
  • Anti-SFRP4 antibody (ab122905) at 0.3 µg/ml + Human uterus lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 40 kDa

Anti-SFRP4 antibody (ab122905) 使用論文

This product has been referenced in:
  • Zhang Z  et al. Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci 20:981-9 (2013). Read more (PubMed: 23322712) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"