製品の概要

  • 製品名SEW 2871
  • 製品の詳細
    Potent, selective S1P1 agonist
  • 生理活性の詳細Potent, selective sphingosine-1-phosphate (S1P1) agonist (EC50 = 13 nM). Does not activate S1P2, S1P3, S1P4 or S1P5 receptors. Cell-permeable and active in vivo.
  • 精製度> 98%

製品の特性

  • 体系名5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
  • 分子量440.36
  • 構造式Chemical Structure
  • 分子式C20H10F6N2OS
  • CAS 番号256414-75-2
  • PubChem 登録番号4077460
  • 保存方法Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 20 mM and in ethanol to 20 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記FC(F)(F)c2sc(cc2c1ccccc1)c3nc(no3)c4cccc(c4)C(F)(F)F
  • 由来

    Synthetic

  • 研究分野

    SEW 2871 (ab120983) 使用論文

    This product has been referenced in:
    • Chi XX & Nicol GD The sphingosine 1-phosphate receptor, S1PR1, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. J Neurophysiol 104:2741-8 (2010). Read more (PubMed: 20844107) »
    • Tsukada YT  et al. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol 50:660-9 (2007). Read more (PubMed: 18091583) »
    • Bolick DT  et al. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler Thromb Vasc Biol 25:976-81 (2005). Read more (PubMed: 15761190) »
    • Sanna MG  et al. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279:13839-48 (2004). Read more (PubMed: 14732717) »

    See 0 Publications for this product

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    Our chemistry team have confirmed that we are not aware of any stability issues, although we haven’t tested it at elevated temperature. Literature melting point data suggests that it is stable at 95°C without any effect on its compo...

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