製品の概要

  • 製品名Anti-SerpinB6 antibody [2F8]
    SerpinB6 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2F8] to SerpinB6
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein of Human SerpinB6 produced in HEK293T cells (NP_004559).

  • ポジティブ・コントロール
    • HEK293T cells transfected with SerpinB6, Carcinoma of Human kidney, Adenocarcinoma of Human endometrium and Carcinoma of Human bladder tissues
  • 特記事項Dilute in PBS (pH7.3) before use.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 48% PBS, 1% BSA, 50% Glycerol
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名2F8
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab119393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 43 kDa.
IHC-P 1/150.

ターゲット情報

  • 機能May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
  • 組織特異性Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
  • 関連疾患Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
  • 配列類似性Belongs to the serpin family. Ov-serpin subfamily.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAP antibody
    • Cytoplasmic antiproteinase antibody
    • Peptidase inhibitor 6 antibody
    • PI-6 antibody
    • PI6 antibody
    • Placental thrombin inhibitor antibody
    • Protease inhibitor 6 (placental thrombin inhibitor) antibody
    • PTI antibody
    • Serpin B6 antibody
    • SERPINB6 antibody
    • SPB6_HUMAN antibody
    see all

Anti-SerpinB6 antibody [2F8] 画像

  • All lanes : Anti-SerpinB6 antibody [2F8] (ab119393) at 1/500 dilution

    Lane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control
    Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB6

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 43 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC203822)
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using ab119393 at a dilution of 1/150.

Anti-SerpinB6 antibody [2F8] (ab119393) 使用論文

ab119393 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119393.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"