Anti-Serotonin transporter 抗体 (ab102048)
Key features and details
- Rabbit polyclonal to Serotonin transporter
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Serotonin transporter antibody
Serotonin transporter 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Serotonin transporter -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-630 of Human Serotonin transporter (AAH69484.1).
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ポジティブ・コントロール
- Mouse lung lysate. Transfected 293T cell line.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab102048の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 71 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 71 kDa. |
ターゲット情報
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機能
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. -
組織特異性
Expressed in platelets (at protein level). -
配列類似性
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. -
翻訳後修飾
Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.
Phosphorylated at Ser-611, Thr-613 and Thr-616. -
細胞内局在
Cell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. - Information by UniProt
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参照データベース
- Entrez Gene: 6532 Human
- Entrez Gene: 15567 Mouse
- Omim: 182138 Human
- SwissProt: P31645 Human
- SwissProt: Q60857 Mouse
- Unigene: 134662 Human
- Unigene: 300318 Mouse
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別名
- 5 HTT antibody
- 5 HTTLPR antibody
- 5 hydroxytryptamine (serotonin) transporter antibody
see all
画像
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Anti-Serotonin transporter antibody (ab102048) at 1/500 dilution + Mouse lung tissue lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 71 kDa -
All lanes : Anti-Serotonin transporter antibody (ab102048) at 1/500 dilution
Lane 1 : Serotonin transporter transfected lysate from 293T cell line
Lane 2 : Non transfected lysate from 293T cell line
Lysates/proteins at 25 µg per lane.
Developed using the ECL technique.
Predicted band size: 71 kDa
Observed band size: 70.3 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (5)
ab102048 は 5 報の論文で使用されています。
- Chen YM et al. Effect of Bacillus subtilis, Enterococcus faecium, and Enterococcus faecalis supernatants on serotonin transporter expression in cells and tissues. World J Gastroenterol 28:532-546 (2022). PubMed: 35316963
- Battaglia DM et al. Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease. Front Microbiol 13:859866 (2022). PubMed: 35391733
- Wang B et al. Ahi1 regulates serotonin production by the GR/ERβ/TPH2 pathway involving sexual differences in depressive behaviors. Cell Commun Signal 20:74 (2022). PubMed: 35643536
- Zhang Y et al. Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT. Cell Mol Biol Lett 25:45 (2020). PubMed: 33061998
- Sherman Horev H et al. Increase in Processing Factors Is Involved in Skewed MicroRNA Expression in Patients with Ulcerative Colitis Who Develop Small Intestine Inflammation after Pouch Surgery. Inflamm Bowel Dis 24:1045-1054 (2018). PubMed: 29688474