Serotonin N-acetyltransferase peptide (ab4975)

製品の概要

製品の詳細

  • 由来
    Synthetic

特性

Our Abpromise guarantee covers the use of ab4975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Phospho-Thr29 AA-NAT, catalog ab3439. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • AA-NAT
    • Aanat
    • Aralkylamine N-acetyltransferase
    • Arylalkylamine N acetyltransferase
    • Serotonin acetylase
    • Serotonin N-acetyltransferase
    • SNAT
    • SNAT_HUMAN
    see all
  • 機能
    Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • 組織特異性
    Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
  • パスウェイ
    Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
  • 関連疾患
    Delayed sleep phase syndrome
  • 配列類似性
    Belongs to the acetyltransferase family. AANAT subfamily.
    Contains 1 N-acetyltransferase domain.
  • 翻訳後修飾
    cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

参考文献

ab4975 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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