Anti-Serine/threonine-protein kinase 4 抗体 (ab13865)


  • 製品名Anti-Serine/threonine-protein kinase 4 antibody
    Serine/threonine-protein kinase 4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Serine/threonine-protein kinase 4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Serine/threonine-protein kinase 4. Synthetic peptide corresponding to amino acids 372-390 (AEDEEEEGTMKRRDETMQP) of human MST-1.

  • ポジティブ・コントロール
    • Jurkat whole cell lysate.
  • 特記事項Stable for 6 months at 4 °C.




Our Abpromise guarantee covers the use of ab13865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 54 kDa.


  • 機能Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
  • 組織特異性Ubiquitously expressed.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SARAH domain.
  • 翻訳後修飾Autophosphorylated on serine and threonine residues.
  • 細胞内局在Cytoplasm. Nucleus. The caspase-cleaved form cycles between the nucleus and cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Kinase responsive to stress antibody
    • Krs2 antibody
    • Mammalian STE20 like protein kinase 1 antibody
    • Mammalian STE20-like protein kinase 1 antibody
    • Mammalian sterile 20 like 1 antibody
    • MST-1 antibody
    • MST1 antibody
    • Serine/threonine kinase 4 antibody
    • Serine/threonine protein kinase Krs 2 antibody
    • Serine/threonine-protein kinase 4 antibody
    • Serine/threonine-protein kinase Krs-2 antibody
    • STE20 like kinase MST1 antibody
    • STE20-like kinase MST1 antibody
    • STK4 antibody
    • STK4_HUMAN antibody
    • TIIAC antibody
    • YSK3 antibody
    see all

Anti-Serine/threonine-protein kinase 4 antibody 画像

  • Predicted band size : 54 kDa
    Western blot analysis of MST1 in 15 ugs of Jurkat cell lysate using ab13865 at 1 ug/ml.


    Western blot analysis of MST1 in 15 ugs of Jurkat cell lysate using ab13865 at 1 ug/ml.

Anti-Serine/threonine-protein kinase 4 antibody (ab13865) 使用論文

ab13865 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. I was able to obtain the immunogen sequence from our source of ab13865. The immunogen is a synthetic peptide corresponding to amino acids 372-390 (AEDEEEEGTMKRRDETMQP) of human MST-1. Synonyms for MST-1 are the following...

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