Anti-Serine Palmitoyltransferase 抗体 (ab23696)

製品の概要

  • 製品名Anti-Serine Palmitoyltransferase antibody
    Serine Palmitoyltransferase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Serine Palmitoyltransferase
  • 特異性This antibody detects human serine palmitoyltransferase subunit SPT2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Sheep, Chicken, Cow, Human, Pig, Xenopus laevis, Zebrafish, African Green Monkey
  • 免疫原

    Synthetic peptide:

    LDRPFDETTYEETED

    , corresponding to amino acids 548-562 of Human Serine Palmitoyltransferase.

  • ポジティブ・コントロール
    • Mouse brain homogenate, rat kidney supernatant, human liver microsome.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab23696 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa.
IHC-P Use a concentration of 1 µg/ml.

ターゲット情報

  • 機能Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate.
  • 組織特異性Widely expressed.
  • パスウェイLipid metabolism; sphingolipid metabolism.
  • 関連疾患Defects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640]. It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness.
  • 配列類似性Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • KIAA0526 antibody
    • LCB 2 antibody
    • LCB2 antibody
    • LCB2a antibody
    • Long chain base biosynthesis protein 2 antibody
    • Long chain base biosynthesis protein 2a antibody
    • Serine palmitoyl CoA transferase 2 antibody
    • Serine palmitoyltransferase 2 antibody
    • Serine palmitoyltransferase long chain base subunit 2 antibody
    • Serine palmitoyltransferase subunit II antibody
    • Serine-palmitoyl-CoA transferase 2 antibody
    • SPT 2 antibody
    • SPT2 antibody
    • SPTC2_HUMAN antibody
    • SPTLC 2 antibody
    • Sptlc2 antibody
    see all

Anti-Serine Palmitoyltransferase antibody 画像

  • All lanes : Anti-Serine Palmitoyltransferase antibody (ab23696) at 1 µg/ml

    Lane 1 : 30ug mouse brain homogenate.
    Lane 2 : 30ug rat kidney supernatant.
    Lane 3 : 30ug human liver microsome.


    Predicted band size : 62 kDa
    Observed band size : 67 kDa (why is the actual band size different from the predicted?)

Anti-Serine Palmitoyltransferase antibody (ab23696) 使用論文

This product has been referenced in:
  • Kawamoto E  et al. Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation. Physiol Rep 4:N/A (2016). Rat . Read more (PubMed: 27482072) »
  • Pesciotta EN  et al. Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients. PLoS One 9:e85504 (2014). WB ; Human . Read more (PubMed: 24454878) »

See all 6 Publications for this product

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Anti-IDH3G antibody (ab118289) Discount code: 42379

Anti-Serine Palmitoyltransferase antibody (ab23696): this antibody has already been shown t...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (Mouse embryonic fibroblast)
Loading amount 50 µg
Specification Mouse embryonic fibroblast
Gel Running Conditions Reduced Denaturing (10-20% tris-tricine)
Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
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投稿 May 12 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"