Anti-Serine Palmitoyltransferase 抗体 (ab23696)
Key features and details
- Rabbit polyclonal to Serine Palmitoyltransferase
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Serine Palmitoyltransferase antibody
Serine Palmitoyltransferase 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Serine Palmitoyltransferase -
由来種
Rabbit -
特異性
This antibody detects human serine palmitoyltransferase subunit SPT2 -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide:
LDRPFDETTYEETED
, corresponding to amino acids 548-562 of Human Serine Palmitoyltransferase. -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
This antibody was affinity purifed. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab23696の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa. |
ターゲット情報
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機能
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate. -
組織特異性
Widely expressed. -
パスウェイ
Lipid metabolism; sphingolipid metabolism. -
関連疾患
Defects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640]. It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness. -
配列類似性
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 9517 Human
- Entrez Gene: 20773 Mouse
- Entrez Gene: 366697 Rat
- Omim: 605713 Human
- SwissProt: O15270 Human
- SwissProt: P97363 Mouse
- Unigene: 435661 Human
- Unigene: 565 Mouse
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別名
- KIAA0526 antibody
- LCB 2 antibody
- LCB2 antibody
see all
画像
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All lanes : Anti-Serine Palmitoyltransferase antibody (ab23696) at 1 µg/ml
Lane 1 : 30ug mouse brain homogenate.
Lane 2 : 30ug rat kidney supernatant.
Lane 3 : 30ug human liver microsome.
Predicted band size: 62 kDa
Observed band size: 67 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (25)
ab23696 は 25 報の論文で使用されています。
- Takeda S et al. Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides. Int J Mol Sci 24:N/A (2022). PubMed: 36613524
- Hwang S et al. Consequences of aneuploidy in human fibroblasts with trisomy 21. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526671
- Takeda S et al. ß-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model. PLoS One 16:e0248150 (2021). PubMed: 33684145
- Zhou Q et al. Effect of Gegen Qinlian Decoction on Hepatic Gluconeogenesis in ZDF Rats with Type 2 Diabetes Mellitus Based on the Farnesol X Receptor/Ceramide Signaling Pathway Regulating Mitochondrial Metabolism and Endoplasmic Reticulum Stress. Evid Based Complement Alternat Med 2021:9922292 (2021). PubMed: 34422083
- Bugajev V et al. Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. J Lipid Res 62:100121 (2021). PubMed: 34560079