製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SEPN1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 507-557 (NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP) of Human SEPN1 (NP_996809)

  • ポジティブ・コントロール
    • HepG2 Cell Lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 2% Sucrose, 1X PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG

アプリケーション

Our Abpromise guarantee covers the use of ab105943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 組織特異性
    Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach.
  • 関連疾患
    Defects in SEPN1 are the cause of myopathy SEPN1-related (M-SEPN1) [MIM:602771]. A group of neuromuscular disorders consisting of four nosological entities: classic multiminicore disease (MmD), rigid spine muscular dystrophy 1 syndrome (RSMD1), desmin-related myopathy with Mallory body-like inclusions (MB-DRM) and congenital fiber-type disproportion. All are clinically characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure.
  • 配列類似性
    Contains 1 EF-hand domain.
  • ドメイン
    The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.
  • 翻訳後修飾
    N-glycosylated (isoform 2).
  • 細胞内局在
    Endoplasmic reticulum membrane. Probably membrane-associated.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CFTD antibody
    • MDRS1 antibody
    • RSMD1 antibody
    • RSS antibody
    • Selenoprotein N antibody
    • Selenoprotein N, 1 antibody
    • SelN antibody
    • SELN_HUMAN antibody
    • sepn1 antibody
    see all

画像

  • Anti-SEPN1 antibody (ab105943) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 58 kDa

プロトコール

参考文献

ab105943 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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