Anti-SENP6 抗体 - Carboxyterminal end (ab59899)

製品の概要

  • 製品名Anti-SENP6 antibody - Carboxyterminal end
    SENP6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SENP6 - Carboxyterminal end
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide selected from the C-terminal region of human SENP6 conjugated to KLH.

  • ポジティブ・コントロール
    • HL60 cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab59899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Detects a band of approximately 126 kDa (predicted molecular weight: 126 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • 組織特異性Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • パスウェイProtein modification; protein sumoylation.
  • 配列類似性Belongs to the peptidase C48 family.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2810017C20Rik antibody
    • FLJ11355 antibody
    • FLJ11887 antibody
    • KIAA0389 antibody
    • KIAA0797 antibody
    • SENP 6 antibody
    • Senp6 antibody
    • SENP6_HUMAN antibody
    • Sentrin specific protease 6 antibody
    • Sentrin-specific protease 6 antibody
    • Sentrin/SUMO specific protease SENP6 antibody
    • Sentrin/SUMO-specific protease SENP6 antibody
    • SSP 1 antibody
    • SSP1 antibody
    • SUMO 1 specific protease 1 antibody
    • SUMO 1 specific protease antibody
    • SUMO-1-specific protease 1 antibody
    • SUMO1 specific protease 1 antibody
    • SUMO1 specific protease antibody
    • SUMO1/sentrin specific peptidase 6 antibody
    • SUSP 1 antibody
    • SUSP1 antibody
    see all

Anti-SENP6 antibody - Carboxyterminal end 画像

  • Anti-SENP6 antibody - Carboxyterminal end (ab59899) at 1/100 dilution + HL60 cell lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 126 kDa
    Observed band size : 126 kDa
  • ab59899 at 1/100 dilution staining SENP6 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used followed by AEC staining.

Anti-SENP6 antibody - Carboxyterminal end (ab59899) 使用論文

ab59899 has not yet been referenced specifically in any publications.

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