製品の概要

  • 製品名Anti-SENP3 antibody [EP4360]
    SENP3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EP4360] to SENP3
  • アプリケーション適用あり: WBmore details
    適用なし: Flow Cyt,ICC,IHC-P or IP
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C terminus of Human SENP3.

  • ポジティブ・コントロール
    • MCF-7, Jurkat and HeLa cell lysates.
  • 特記事項

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名EP4360
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 65 kDa.
  • 追加情報Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • ターゲット情報

    • 機能Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
    • 配列類似性Belongs to the peptidase C48 family.
    • 細胞内局在Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
    • Information by UniProt
    • 参照データベース
    • 別名
      • SENP3 antibody
      • SENP3_HUMAN antibody
      • Sentrin / SUMO specific protease 3 antibody
      • Sentrin specific protease 3 antibody
      • Sentrin-specific protease 3 antibody
      • Sentrin/SUMO-specific protease SENP3 antibody
      • SMT3IP1 antibody
      • SSP3 antibody
      • SUMO 1 specific protease 3 antibody
      • SUMO-1-specific protease 3 antibody
      • SUMO1 specific protease 3 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
      • SUSP3 antibody
      see all

    Anti-SENP3 antibody [EP4360] 画像

    • All lanes : Anti-SENP3 antibody [EP4360] (ab124790) at 1/1000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 65 kDa

    Anti-SENP3 antibody [EP4360] (ab124790) 使用論文

    ab124790 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124790.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"