製品の概要

  • 製品名Anti-SENP3 antibody
    SENP3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SENP3
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide from an internal region of Human SENP3

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab58419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • 配列類似性Belongs to the peptidase C48 family.
  • 細胞内局在Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
  • Information by UniProt
  • 参照データベース
  • 別名
    • SENP3 antibody
    • SENP3_HUMAN antibody
    • Sentrin / SUMO specific protease 3 antibody
    • Sentrin specific protease 3 antibody
    • Sentrin-specific protease 3 antibody
    • Sentrin/SUMO-specific protease SENP3 antibody
    • SMT3IP1 antibody
    • SSP3 antibody
    • SUMO 1 specific protease 3 antibody
    • SUMO-1-specific protease 3 antibody
    • SUMO1 specific protease 3 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
    • SUSP3 antibody
    see all

Anti-SENP3 antibody 画像

  • Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue with ab58419 at 1/50 dilution, in the absence or presence of the immunizing peptide peptide.

Anti-SENP3 antibody (ab58419) 使用論文

ab58419 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"