製品の概要

  • 製品名Anti-Semaphorin 7a antibody [MEM-150]
    Semaphorin 7a 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MEM-150] to Semaphorin 7a
  • 特異性Human CD108 (JMH blood group antigen).
  • アプリケーション適用あり: ICC/IF, Flow Cyt, IP, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Tissue/ cell preparation (Human). (T cell line HPB-ALL).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration. PubMed: 22896629
Flow Cyt Use a concentration of 4 µg/ml. ab91545-Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Use under non-reducing conditions.

ターゲット情報

  • 機能Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • 組織特異性Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
  • 配列類似性Belongs to the semaphorin family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 PSI domain.
    Contains 1 Sema domain.
  • 細胞内局在Cell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 108 antibody
    • CD108 antibody
    • CD108 antigen antibody
    • CDw108 antibody
    • H Sema K1 antibody
    • H Sema L antibody
    • H-SEMA-K1 antibody
    • H-Sema-L antibody
    • JMH antibody
    • JMH blood group antigen antibody
    • John Milton Hagen blood group H Sema K1 antibody
    • John Milton Hargen human blood group Ag antibody
    • John-Milton-Hargen human blood group Ag antibody
    • MGC126692 antibody
    • MGC126696 antibody
    • SEM7A_HUMAN antibody
    • Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A antibody
    • Sema K1 antibody
    • Sema L antibody
    • SEMA7A antibody
    • SEMAK1 antibody
    • SEMAL antibody
    • Semaphorin 7A GPI membrane anchor antibody
    • Semaphorin K1 antibody
    • Semaphorin L antibody
    • Semaphorin-7A antibody
    • Semaphorin-K1 antibody
    • Semaphorin-L antibody
    • Semaphorin7a antibody
    see all

Anti-Semaphorin 7a antibody [MEM-150] (ab8222) 使用論文

This product has been referenced in:
  • Drukker M  et al. Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol 30:531-42 (2012). Human . Read more (PubMed: 22634564) »
  • Sultana H  et al. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-ß1/Smad6 signaling. J Immunol 189:3150-8 (2012). WB, ICC/IF ; Mouse . Read more (PubMed: 22896629) »

See all 6 Publications for this product

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"