製品の概要

  • 製品名Anti-Seladin 1 antibody
    Seladin 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Seladin 1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 431-480 (AELYIDIGAY GEPRVKHFEA RSCMRQLEKF VRSVHGFQML YADCYMNREE) of Human Seladin 1 (NP_055577).

  • ポジティブ・コントロール
    • THP1 cell lysate

アプリケーション

Our Abpromise guarantee covers the use of ab98345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
  • 組織特異性Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
  • パスウェイSteroid biosynthesis; cholesterol biosynthesis.
  • 関連疾患Desmosterolosis (DESMOS) [MIM:602398]: Rare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 配列類似性Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
    Contains 1 FAD-binding PCMH-type domain.
  • 細胞内局在Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 24 dehydrocholesterol reductase antibody
    • 24-dehydrocholesterol reductase antibody
    • 3 beta hydroxysterol delta 24 reductase antibody
    • 3-beta-hydroxysterol delta-24-reductase antibody
    • DCE antibody
    • Delta(24)-sterol reductase antibody
    • Desmosterol to cholesterol enzyme antibody
    • DHC24_HUMAN antibody
    • Dhcr24 antibody
    • Diminuto dwarf1 homolog antibody
    • Diminuto/dwarf1 homolog antibody
    • KIAA0018 antibody
    • Nbla03646 antibody
    • Seladin-1 antibody
    • SELADIN1 antibody
    • Selective AD indicator 1 antibody
    • Selective Alzheimer's Disease Indicator 1 antibody
    see all

Anti-Seladin 1 antibody 画像

  • Anti-Seladin 1 antibody (ab98345) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 60 kDa

Anti-Seladin 1 antibody (ab98345) 使用論文

ab98345 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"