Anti-Secretory Component Glycoprotein 抗体 [SPM217] (ab17921)

製品の概要

  • 製品名Anti-Secretory Component Glycoprotein antibody [SPM217]
    Secretory Component Glycoprotein 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SPM217] to Secretory Component Glycoprotein
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Full length native protein (purified) (Human).

  • エピトープNot determined
  • ポジティブ・コントロール
    • Small intestine. Colon carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab17921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF
IHC-P
  • 追加情報
    IF: Use at an assay dependent dilution.
    IHC-P: 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. For staining of formalin-fixed tissues, digest sections with trypsin at 1mg/ml PBS, 15 min at room temp.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    • 組織特異性Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
    • 関連疾患Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
    • 細胞内局在Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ECM 1 antibody
      • Ecm1 antibody
      • ECM1_HUMAN antibody
      • Extracellular matrix protein 1 antibody
      • Secretory component p85 antibody
      • URBWD antibody
      see all

    Anti-Secretory Component Glycoprotein antibody [SPM217] 画像

    • Human colon carcinoma stained with ab17921.

    Anti-Secretory Component Glycoprotein antibody [SPM217] (ab17921) 使用論文

    ab17921 has not yet been referenced specifically in any publications.

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