製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 配列
      An 18 amino acid synthetic peptide whose sequences are derived from rat COP II protein. The sequence of this peptide is (amino to carboxy terminus): M(1)TTYLEFIQQNEERDGVR(18) - C.

特性

Our Abpromise guarantee covers the use of ab4960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat COP II, catalog ab3351. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • CLSD
    • Protein transport protein Sec23A
    • SC23A_HUMAN
    • Sec23 homolog A (S. cerevisiae)
    • SEC23-related protein A
    • sec23a
    see all
  • 機能
    Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
  • 関連疾患
    Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.
  • 配列類似性
    Belongs to the SEC23/SEC24 family. SEC23 subfamily.
  • 細胞内局在
    Smooth endoplasmic reticulum membrane. Golgi apparatus membrane. In the ribosome-free transitional face of the ER and associated vesicles.
  • Information by UniProt

参考文献

ab4960 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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