Anti-SCRIBBLE 抗体 [EPR4140(2)] (ab125080)

製品の概要

• 製品名Anti-SCRIBBLE antibody [EPR4140(2)]
  SCRIBBLE 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR4140(2)] to SCRIBBLE
• アプリケーション適用あり: WB, ICC, Flow Cytmore details
  適用なし: IHC-P or IP
• 種交差性
  交差種: Human
  非交差種: Mouse, Rat
• 免疫原

  Synthetic peptide, corresponding to residues near the C-terminus of Human SCRIBBLE.

• ポジティブ･コントロール
  • 293T, HeLa and MCF7 cell lysates; permeabilized 293T cells.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファーpH: 7.40
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 0.05% BSA
• 精製度Tissue culture supernatant
• ポリ/モノモノクローナル
• クローン名EPR4140(2)
• アイソタイプIgG
• 研究分野
  • Microbiology
  • Organism
  • Virus
  • DNA Virus
  • double stranded DNA Virus
  • Human Papillomavirus

関連製品

• Positive Controls
  • MCF7 membrane extract lysate (ab29539)
  • HeLa membrane extract lysate (ab29547)

アプリケーション

ターゲット情報

• 機能Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
• 組織特異性Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
• 配列類似性Belongs to the LAP (LRR and PDZ) protein family.
  Contains 16 LRR (leucine-rich) repeats.
  Contains 4 PDZ (DHR) domains.
• 翻訳後修飾Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
• 細胞内局在Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.

• Target information above from: UniProt accession Q14160 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 23513 Human
  • Omim: 607733 Human
  • SwissProt: Q14160 Human
  • Unigene: 436329 Human
• 別名
  • CRIB 1 antibody
  • CRIB1 antibody
  • hScrib antibody

  • LAP 4 antibody
  • LAP4 antibody
  • PDZ domain protein scribble antibody
  • Protein LAP4 antibody
  • Protein scribble homolog antibody
  • SCRB 1 antibody
  • SCRB1 antibody
  • SCRIB 1 antibody
  • Scrib antibody
  • SCRIB_HUMAN antibody
  • SCRIB1 antibody
  • Scribble antibody
  • Scribble homolog 1 antibody
  • scribbled homolog (Drosophila) antibody
  • Vartul antibody

  see all