製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SCO2
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the C-terminus of Human SCO2.

  • ポジティブ・コントロール
    • IHC-P: Human Lung, Respiratory Epithelium and Human Kidney tissues

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
  • 組織特異性
    Ubiquitous.
  • 関連疾患
    Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
  • 配列類似性
    Belongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cytochrome oxidase deficient homolog 2 antibody
    • MGC125823 antibody
    • MGC125825 antibody
    • OTTHUMP00000196774 antibody
    • OTTHUMP00000196775 antibody
    • Protein SCO2 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient, yeast) homolog 2 antibody
    • SCO 1L antibody
    • SCO 2 antibody
    • SCO cytochrome oxidase deficient homolog 2 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 2 antibody
    • SCO1L antibody
    • SCO2 antibody
    • SCO2_HUMAN antibody
    • Synthesis of cytochrome c oxidase 2 antibody
    see all

画像

  • Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Kidney (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

参考文献

ab115877 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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