製品の概要

  • 製品名Anti-SCO1 antibody
    SCO1 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to SCO1
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human protein (NP_004580.1)

  • ポジティブ・コントロール
    • WB: lysate from Human liver or HeLa cells. ICC/IF: HepG2 cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa.
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • 組織特異性Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • 関連疾患Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 配列類似性Belongs to the SCO1/2 family.
  • 細胞内局在Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Anti-SCO1 antibody 画像

  • ab88658 at 10 µg/ml staining SCO1 by immunofluorescence in paraformaldehyde fixed, permeabilized HepG2 cells.
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 34 kDa
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 34 kDa
  • All lanes : Anti-SCO1 antibody (ab88658) at 1 µg/ml

    Lane 1 : SCO1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 34 kDa
    Observed band size : 33 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.

Anti-SCO1 antibody (ab88658) 使用論文

ab88658 has not yet been referenced specifically in any publications.

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