製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SCO1
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the center of Human SCO1.

  • ポジティブ・コントロール
    • IHC-P: Human Heart and Human Brain Cortex tissues

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • 組織特異性
    Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • 関連疾患
    Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 配列類似性
    Belongs to the SCO1/2 family.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Anti-SCO1 antibody 画像

  • Human Heart (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SCO1 antibody (ab115873) 使用論文

ab115873 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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