製品の概要

  • 製品名
    Anti-SCN3B antibody
  • 製品の詳細
    Rabbit polyclonal to SCN3B
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    A region within synthetic peptide: RPEGGKDFLI YEYRNGHQEV ESPFQGRLQW NGSKDLQDVS ITVLNVTLND, corresponding to amino acids 65-114 of Human SCN3B

  • ポジティブ・コントロール
    • Fetal brain lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab48552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • 関連疾患
    Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7) [MIM:613120]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 配列類似性
    Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1110001K16Rik antibody
    • 4833414B02Rik antibody
    • HSA243396 antibody
    • KIAA1158 antibody
    • MGC136997 antibody
    • MGC80155 antibody
    • Scn3b antibody
    • SCN3B_HUMAN antibody
    • SCNB3 antibody
    • Sodium channel subunit beta-3 antibody
    • Sodium channel, beta 3 subunit antibody
    • sodium channel, voltage-gated, type III, beta antibody
    see all

画像

  • Anti-SCN3B antibody (ab48552) at 0.5 µg/ml + fetal brain lysate at 10 µg with 5% skimmed milk in PBS buffer

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa

プロトコール

参考文献

This product has been referenced in:
  • Shy D  et al. PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Circulation 130:147-60 (2014). Read more (PubMed: 24895455) »
  • Ho C  et al. Differential expression of sodium channel ß subunits in dorsal root ganglion sensory neurons. J Biol Chem : (2012). WB ; Rat . Read more (PubMed: 22408255) »

See all 3 Publications for this product

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