製品の概要

  • 製品名Anti-SCN1B antibody
    SCN1B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SCN1B
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to a sequence at the N-terminal of Human SCN1B

  • ポジティブ・コントロール
    • Rat brain and testicular tissue lysates; MCF7, HeLa, MM231 and HT1080 whole cell lysates.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).

ターゲット情報

  • 機能Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • 組織特異性Abundantly expressed in skeletal muscle, heart and brain.
  • 関連疾患Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in SCN1B are the cause of Brugada syndrome type 5 (BRS5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 配列類似性Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GEFSP1 antibody
    • SCN1B antibody
    • SCN1B_HUMAN antibody
    • sodium channel beta 1 subunit antibody
    • Sodium channel subunit beta 1 antibody
    • Sodium channel subunit beta-1 antibody
    • Sodium channel voltage gated type I beta antibody
    • Sodium channel voltage gated type I beta subunit antibody
    see all

Anti-SCN1B antibody 画像

  • All lanes : Anti-SCN1B antibody (ab86931) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat testicular tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : MM231 whole cell lysate
    Lane 6 : HT1080 whole cell lysate


    Predicted band size : 25 kDa
    Observed band size : 25 kDa

Anti-SCN1B antibody (ab86931) 使用論文

ab86931 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 50 µg
Gel Running Conditions Non-reduced Non-Denaturing (Native)
Sample Rat Cell lysate - whole cell (cardiamyocyte)
Specification cardiamyocyte
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 0.05% · Temperature: RT°C
Username

Mr. Kuihao Chen

Verified customer

投稿 Dec 18 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"