Anti-Sclerostin 抗体 [RM0129-4D77] (ab86465)
Key features and details
- Rat monoclonal [RM0129-4D77] to Sclerostin
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
製品の概要
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製品名
Anti-Sclerostin antibody [RM0129-4D77]
Sclerostin 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0129-4D77] to Sclerostin -
由来種
Rat -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant full length protein (Mouse)
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ポジティブ・コントロール
- WB: Mouse embryonic tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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特記事項(精製)
IgG fraction of cell culture supernatant purified by Protein A/G affinity chromatography and 0.2 µm filtered. -
ポリ/モノ
モノクローナル -
クローン名
RM0129-4D77 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab86465の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 24 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 24 kDa. |
ターゲット情報
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機能
Negative regulator of bone growth. -
組織特異性
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days. -
関連疾患
Defects in SOST are the cause of sclerosteosis (SOST) [MIM:269500]; also known as cortical hyperostosis with syndactyly. SOST is an autosomal recessive sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.
Note=A 52 kb deletion downstream of SOST results in SOST transcription suppression and is a cause of van Buchem disease (VBCH) [MIM:239100]; also known as hyperostosis corticalis generalisata. VBCH is an autosomal recessive sclerosing bone dysplasia characterized by endosteal hyperostosis of the mandible, skull, ribs, clavicles, and diaphyses of the long bones. Affected patients present a symmetrically increased thickness of bones, most frequently found as an enlarged jawbone, but also an enlargement of the skull, ribs, diaphysis of long bones, as well as tubular bones of hands and feet. The clinical consequence of increased thickness of the skull include facial nerve palsy causing hearing loss, visual problems, neurological pain, and, very rarely, blindness as a consequence of optic atrophy. Serum alkaline phosphatase levels are elevated. -
配列類似性
Belongs to the sclerostin family.
Contains 1 CTCK (C-terminal cystine knot-like) domain. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 74499 Mouse
- SwissProt: Q99P68 Mouse
- Unigene: 265602 Mouse
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別名
- BEER antibody
- CDD antibody
- Cortical hyperostosis with syndactyly antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab86465 は論文での使用が確認できていません。