SCH-58261, A2A antagonist (ab120439)
Key features and details
- Potent, highly selective A2A antagonist
- CAS Number: 160098-96-4
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SCH-58261, A2A antagonist -
製品の詳細
Potent, highly selective A2A antagonist -
生理活性の詳細
Potent, highly selective A2A receptor antagonist. (Ki values are 1-2, 289 and >10000 nM at A2A, A1 and A3 receptors, respectively). Displays therapeutic effects in animal Parkinson's models and elicits locomotor sensitization in vivo.
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CAS 番号
160098-96-4 -
構造式
製品の特性
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体系名
2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine -
分子量
345.36 -
分子式
C18H15N7O -
PubChem 登録番号
176408 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Nc3nc2c(cnn2CCc1ccccc1)c4nc(nn34)c5ccco5 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120439 は 3 報の論文で使用されています。
- Gao Y et al. H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury. Cell Death Discov 8:475 (2022). PubMed: 36456564
- Li YF et al. Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. Theranostics 8:5713-5730 (2018). PubMed: 30555576
- Acton D & Miles GB Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine. PLoS One 10:e0134488 (2015). PubMed: 26252389