製品の概要

  • 製品名SCH-58261
  • 製品の詳細
    Potent, highly selective A2A antagonist
  • 生理活性の詳細Potent, highly selective A2A receptor antagonist. (Ki values are 1-2, 289 and >10000 nM at A2A, A1 and A3 receptors, respectively). Displays therapeutic effects in animal Parkinson's models and elicits locomotor sensitization in vivo.
  • 精製度> 99%

製品の特性

    SCH-58261 (ab120439) 使用論文

    This product has been referenced in:
    • Hsu CW  et al. Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice. J Biomed Sci 17:4 (2010). Read more (PubMed: 20074377) »
    • Kelsey JE  et al. The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat. Psychopharmacology (Berl) 201:529-39 (2009). Read more (PubMed: 18791705) »
    • Shah U  et al. Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists. Bioorg Med Chem Lett 18:4204-9 (2008). Read more (PubMed: 18558486) »

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