Anti-Scavenger Receptor BI + BII 抗体 (ab36970)
Key features and details
- Rabbit polyclonal to Scavenger Receptor BI + BII
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Scavenger Receptor BI + BII antibody -
製品の詳細
Rabbit polyclonal to Scavenger Receptor BI + BII -
由来種
Rabbit -
特異性
ab36970 is specific for SR-BI and SR-BII. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Rat -
免疫原
Synthetic peptide, corresponding to extracellular amino acids 230-280 of Scavenger Receptor BI + BII
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab36970の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000. Predicted molecular weight: 82 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 82 kDa. |
ターゲット情報
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関連性
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells. -
細胞内局在
Lysosome; lysosomal membrane; multi-pass membrane protein. -
参照データベース
- Entrez Gene: 12492 Mouse
- Entrez Gene: 20778 Mouse
- Entrez Gene: 117106 Rat
- Entrez Gene: 25073 Rat
- SwissProt: O35114 Mouse
- SwissProt: Q61009 Mouse
- SwissProt: P27615 Rat
- SwissProt: P97943 Rat
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別名
- CD36 and LIMPII Analogous 1 antibody
- CD36L1 antibody
- CD36L2 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (4)
ab36970 は 4 報の論文で使用されています。
- Radulovic S et al. Endothelial lipase increases eNOS activating capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158612 (2020). PubMed: 31923467
- Balasubramanian K et al. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal 8:ra95 (2015). PubMed: 26396268
- Badeau RM et al. Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters. J Steroid Biochem Mol Biol 116:44-9 (2009). Blocking ; Human . PubMed: 19406243
- Acín S et al. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice. J Biochem (Tokyo) 140:383-91 (2006). PubMed: 16873395