製品の概要

  • 製品名
    SB 699551 dihydrochloride
  • 製品の詳細
    Selective 5-HT5A receptor antagonist
  • 別名
    • SB 699551-A
  • 生理活性の詳細
    Selective 5-HT5A receptor antagonist (pKi values are 8.3, for 5-HT5A and < 6.0 for 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors). Increases extracellular 5-HT levels.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Thomas DR 5-ht5A receptors as a therapeutic target. Pharmacol Ther 111:707-14 (2006). Read more (PubMed: 16516972) »
  • Thomas DR  et al. SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology 51:566-77 (2006). Read more (PubMed: 16846620) »
  • Corbett DF  et al. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg Med Chem Lett 15:4014-8 (2005). Read more (PubMed: 16002289) »

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