製品の概要

  • 製品名
    SB 415286
  • 製品の詳細
    Potent, selective GSK3 inhibitor
  • 生理活性の詳細
    Potent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Mirlashari MR  et al. Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway. Leuk Res 36:499-508 (2012). Read more (PubMed: 22177455) »
  • Forde JE & Dale TC Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64:1930-44 (2007). Read more (PubMed: 17530463) »
  • Cross DA  et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem 77:94-102 (2001). Read more (PubMed: 11279265) »
  • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »

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