製品の概要

  • 製品名
    SB 334867
  • 製品の詳細
    Selective OX1 receptor antagonist
  • 生理活性の詳細
    Selective OX1 receptor antagonist. Inhibits orexin-A induced intracellular calcium release (IC50 = 226 nM). Shows anxiolytic, sedative and anorectic effects in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Staples LG & Cornish JL The orexin-1 receptor antagonist SB-334867 attenuates anxiety in rats exposed to cat odor but not the elevated plus maze: an investigation of Trial 1 and Trial 2 effects. Horm Behav 65:294-300 (2014). Read more (PubMed: 24397997) »
  • Azhdari-Zarmehri H  et al. Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test. Pharmacol Biochem Behav 112:64-70 (2013). Read more (PubMed: 24125787) »
  • Smart D  et al. SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132:1179-82 (2001). Read more (PubMed: 11250867) »

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