製品の概要

  • 製品名SB 328437
  • 製品の詳細
    Highly potent and selective CCR3 antagonist
  • 生理活性の詳細Highly potent and selective CCR3 antagonist (IC50 = 4 nM). Shows >2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD4 receptors. Inhibits Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC50 values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.
  • 精製度> 99%

製品の特性

    SB 328437 (ab120648) 使用論文

    This product has been referenced in:
    • Li B  et al. Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8. J Cell Physiol 226:2398-405 (2011). Read more (PubMed: 21660963) »
    • Mori A  et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol 19:913-21 (2007). Read more (PubMed: 17804691) »
    • White JR  et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem 275:36626-31 (2000). Read more (PubMed: 10969084) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120648.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"