製品の概要

  • 製品名
    SB 328437
  • 製品の詳細
    Highly potent and selective CCR3 antagonist
  • 生理活性の詳細
    Highly potent and selective CCR3 antagonist (IC50 = 4 nM). Shows >2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD4 receptors. Inhibits Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC50 values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Li B  et al. Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8. J Cell Physiol 226:2398-405 (2011). Read more (PubMed: 21660963) »
  • Mori A  et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol 19:913-21 (2007). Read more (PubMed: 17804691) »
  • White JR  et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem 275:36626-31 (2000). Read more (PubMed: 10969084) »

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