製品の概要

  • 製品名SB 297006
  • 製品の詳細
    Potent, selective CCR3 antagonist
  • 生理活性の詳細Highly potent, selective CCR3 antagonist (IC50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC50 values are 210, 90 and 80 nM, respectively).
  • 精製度> 99%

製品の特性

    SB 297006 (ab120821) 使用論文

    This product has been referenced in:
    • Mori A  et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol 19:913-21 (2007). Read more (PubMed: 17804691) »
    • White JR  et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem 275:36626-31 (2000). Read more (PubMed: 10969084) »

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