製品の概要

  • 製品名
    SB-277011-A dihydrochloride
  • 製品の詳細
    Potent, highly selective D3 antagonist
  • 生理活性の詳細
    Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.
  • 精製度
    > 98%

法規制情報

製品の特性

参考文献

This product has been referenced in:
  • Thanos PK  et al. The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. Pharmacol Biochem Behav 89:499-507 (2008). Read more (PubMed: 18329700) »
  • Ross JT  et al. Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats. Eur J Pharmacol 559:173-9 (2007). Read more (PubMed: 17303116) »
  • Thanos PK  et al. The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats. Pharmacol Biochem Behav 81:190-7 (2005). Read more (PubMed: 15894078) »

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