SB-277011-A dihydrochloride, D3 antagonist (ab120567)
Key features and details
- Potent, highly selective D3 antagonist
- CAS Number: 1226917-67-4
- Soluble in water to 10 mM, in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SB-277011-A dihydrochloride, D3 antagonist -
製品の詳細
Potent, highly selective D3 antagonist -
生理活性の詳細
Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.
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CAS 番号
1226917-67-4 -
構造式
製品の特性
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体系名
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride -
分子量
511.49 -
分子式
C28H30N4O.2HCl -
PubChem 登録番号
75358288 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM, in ethanol to 10 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45.Cl.Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120567 は 1 報の論文で使用されています。
- Rodgers HM et al. Dopamine D1 and D3 receptor modulators restore morphine analgesia and prevent opioid preference in a model of neuropathic pain. Neuroscience 406:376-388 (2019). PubMed: 30910641