製品の概要

  • 製品名
    SB 271046 hydrochloride
  • 製品の詳細
    Potent, selective 5-HT6 antagonist
  • 生理活性の詳細
    Potent and selective 5-HT6 receptor antagonist (Ki = 1-2 nM). Displays >200-fold selectivity for 5-HT6 receptors (vs. other receptor binding sites and ion channels). Poor penetration of the blood-brain barrier. Nootropic effects in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Da Silva Costa-Aze V  et al. Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behav Brain Res 222:134-40 (2011). Read more (PubMed: 21443908) »
  • Routledge C  et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol 130:1606-12 (2000). Read more (PubMed: 10928964) »
  • Bromidge SM  et al. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem 42:202-5 (1999). Read more (PubMed: 9925723) »

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