製品の概要

  • 製品名
    SB 242084 hydrochloride
  • 製品の詳細
    Potent, selective 5-HT2C antagonist
  • 別名
    • SB242084
  • 生理活性の詳細

    Potent, selective 5-HT2C antagonist (pKi values are 9 (5-HT2C), 7 (5-HT2B), 6.8 (5-HT2A), 6.4 (5-HT1A), 6.4 (5-HT1B), 6.4 (5-HT1D), 6 (5-HT1E), <6.1 (5-HT1F), <5.5 (5-HT4), 6 (5-HT6), 6.1 (5-HT7), 6.2 (D2), 6.2 (D3) and <5 (α1)). Blood-brain barrier permeable. Anxiolytic activity in vivo.

  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Kelly CR & Sharif NA Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line. J Pharmacol Exp Ther 317:1254-61 (2006). Read more (PubMed: 16517693) »
  • Kantor S  et al. Despite similar anxiolytic potential, the 5-hydroxytryptamine 2C receptor antagonist SB-242084 [6-chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl carbamoyl] indoline] and chlordiazepoxide produced differential effects on electroencephalogram power spectra. J Pharmacol Exp Ther 315:921-30 (2005). Read more (PubMed: 16085759) »
  • Bromidge SM  et al. 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J Med Chem 40:3494-6 (1997). Read more (PubMed: 9357513) »
  • Kennett GA  et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36:609-20 (0). Read more (PubMed: 9225286) »

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