製品の概要

  • 製品名
    SB 225002
  • 製品の詳細
    A selective non-peptide CXCR2 antagonist
  • 生理活性の詳細
    A selective non-peptide CXCR2 antagonist. Inhibits IL-8 binding to CXCR2 (IC50 = 22 nM).
  • 精製度
    > 95%

製品の特性

  • 体系名
    N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
  • 分子量
    352.14
  • 構造式
    Chemical Structure
  • 分子式
    C13H10BrN3O4
  • CAS 番号
    182498-32-4
  • 保存方法
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in DMSO to 75 mM and in ethanol to 25 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    OC1=CC([N+]([O-])=O)=CC=C1NC(NC2=C(Br)C=CC=C2)=O
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Catusse J  et al. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochem Pharmacol 65:813-21 (2003). Read more (PubMed: 12628493) »
  • Lane BR  et al. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J Virol 75:8195-202 (2001). Read more (PubMed: 11483765) »
  • White JR  et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273:10095-8 (1998). Read more (PubMed: 9553055) »

See 0 Publications for this product

レビューと Q&A

We can only advise based on literature and unfortunately I was unable to find anything specifically on the interaction of SB225002 and the anesthetics mentioned. However, looking at the literature, compounds such as Isoflurane, ketamine and xylazine se...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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