製品の概要

  • 製品名Anti-SAV1 antibody
    SAV1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to SAV1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: HTAEIPDWLQ VYARAPVKYD HILKWELFQL ADLDTYQGML KLLFMKELEQ IVKMYEAYRQ ALLTELENRK QRQQWYAQQH GKNF, corresponding to amino acids 300-384 of Human SAV1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
    • 組織特異性Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
    • 配列類似性Contains 1 SARAH domain.
      Contains 2 WW domains.
    • 翻訳後修飾Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
    • 細胞内局在Nucleus. Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 1700040G09Rik antibody
      • 45 kDa WW domain protein antibody
      • hWW 45 antibody
      • hWW45 antibody
      • Protein salvador homolog 1 antibody
      • salvador family WW domain containing protein 1 antibody
      • salvador homolog 1 (Drosophila) antibody
      • Salvador homolog 1 antibody
      • Salvador, Drosophila, homolog of antibody
      • SAV 1 antibody
      • SAV antibody
      • SAV1 antibody
      • SAV1_HUMAN antibody
      • WW 45 antibody
      • WW domain containing antibody
      • WW domain-containing adaptor 45 antibody
      • WW domain-containing protein, 45-KD antibody
      • WW45 antibody
      • WW45 protein antibody
      • WWP 4 antibody
      • WWP4 antibody
      see all

    Anti-SAV1 antibody 画像



    • Predicted band size : 45 kDa
      SAV1 antibody (ab57534) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-SAV1 antibody (ab57534) 使用論文

    ab57534 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57534.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"