Anti-SAP130 抗体 (ab114978)
Key features and details
- Rabbit polyclonal to SAP130
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SAP130 antibody
SAP130 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SAP130 -
由来種
Rabbit -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide corresponding to Human SAP130 aa 998-1048.
Database link: Q9H0E3 -
ポジティブ・コントロール
- HeLa whole cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab114978 is affinity purified using an epitope specific to SAP130 immobilized on solid support -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab114978の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IP |
Use at 2-5 µg/mg of lysate.
|
特記事項 |
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IP
Use at 2-5 µg/mg of lysate. |
ターゲット情報
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機能
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. -
組織特異性
Expressed in various cancer cell ines. -
配列類似性
Belongs to the SAP130 family. -
ドメイン
The N-terminus may interact with a transcriptional coactivator.
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors. -
翻訳後修飾
Acetylated. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 424756 Chicken
- Entrez Gene: 79595 Human
- Entrez Gene: 269003 Mouse
- Entrez Gene: 307527 Rat
- Omim: 609697 Human
- SwissProt: Q5F3U0 Chicken
- SwissProt: Q9H0E3 Human
- SwissProt: Q8BIH0 Mouse
see all -
別名
- 130 kDa Sin3-associated polypeptide antibody
- FLJ12761 antibody
- Histone deacetylase complex subunit SAP130 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab114978 は 2 報の論文で使用されています。
- Li W et al. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J Clin Invest 127:3421-3440 (2017). PubMed: 28805661
- Salas-Armenteros I et al. Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. EMBO J 36:3532-3547 (2017). PubMed: 29074626