製品の概要

  • 製品名Anti-SALL1 antibody [K9814]
    SALL1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [K9814] to SALL1
  • 特異性This antibody is specific for SALL1.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Baculovirus-expressed recombinant fragment, corresponding to amino acids 258/499 of Human SALL1

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab41974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use a concentration of 0.5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 140 kDa.

ターゲット情報

  • 機能Transcriptional repressor involved in organogenesis.
  • 組織特異性Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver.
  • 関連疾患Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS) [MIM:107480]. TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss.
    Defects in SALL1 may cause a phenotype overlapping with TBS, similar to bronchio-oto-renal syndrome (BOR) [MIM:113650]. BOR is an autosomal dominant disorder, manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation.
  • 配列類似性Belongs to the sal C2H2-type zinc-finger protein family.
    Contains 9 C2H2-type zinc fingers.
  • 発生段階In fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HSal1 antibody
    • Sal like protein 1 antibody
    • Sal-1 antibody
    • Sal-like protein 1 antibody
    • Sal1 antibody
    • SALL1 antibody
    • SALL1_HUMAN antibody
    • Spalt-like transcription factor 1 antibody
    • TBS antibody
    • Zinc finger protein 794 antibody
    • Zinc finger protein SALL1 antibody
    • Zinc finger protein Spalt-1 antibody
    see all

Anti-SALL1 antibody [K9814] (ab41974) 使用論文

ab41974 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (Mouse embryonic kidney at 13.5 dpc)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Tris-EDTA ph9
Permeabilization No
Specification Mouse embryonic kidney at 13.5 dpc
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Fixative Paraformaldehyde
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投稿 Sep 16 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"