機能The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
組織特異性Expression level increases during S phase and drops in G2 phase (at protein level).
パスウェイProtein modification; protein sumoylation.
配列類似性Belongs to the ubiquitin-activating E1 family.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.