The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-S100 beta antibody (ab14688)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: PBS, pH 7.4
Protein S100 B
S 100 calcium binding protein beta chain
S 100 protein beta chain
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium binding protein beta (neural)
S100 calcium-binding protein B
S100 protein beta chain
機能Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
組織特異性Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
配列類似性Belongs to the S-101 family. Contains 2 EF-hand domains.