The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報AP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 11 kDa. Dilution optimised using Chromogenic detection. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
機能Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
組織特異性Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
配列類似性Belongs to the S-101 family. Contains 2 EF-hand domains.