製品の概要

  • 製品名
    (S)-Timolol maleate
  • 製品の詳細
    Potent non-selective β adrenoceptor antagonist
  • 生理活性の詳細
    Potent non-selective β adrenoceptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes, respectively). 50% bioavailability following oral administration. Does not cross the blood-brain barrier.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Mandagere AK  et al. Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates. J Med Chem 45:304-11 (2002). Read more (PubMed: 11784135) »
  • Phan TM  et al. Ophthalmic beta-blockers: determination of plasma and aqueous humor levels by a radioreceptor assay following multiple doses. J Ocul Pharmacol 7:243-52 (1991). Read more (PubMed: 1686051) »
  • Louis WJ  et al. Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats. Br J Pharmacol 75:441-6 (1982). Read more (PubMed: 6121594) »
  • Hall RA  et al. Timolol maleate, a new beta-adrenergic receptor blocking agent. Arch Int Pharmacodyn Ther 213:251-63 (1975). Read more (PubMed: 238479) »

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