生理活性の詳細Selective D2-like dopamine antagonist (Ki values are ~ 0.015, ~ 0.013, and 1 μM at D2, D3, and D4 receptors, respectively). Active enantiomer of Sulpiride (ab120578). Antipsychotic and prokinetic agent.
保存方法Store at +4°C. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 100 mM and in ethanol to 25 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Merlo S et al. Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype. Neuropharmacology60:892-900 (2011).
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Ichikawa J & Meltzer HY R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther291:1227-32 (1999).
Read more (PubMed: 10565846) »
Zuccato E et al. The effects of S(-) and R(+) sulpiride, metoclopramide, cisapride and domperidone on the small intestine suggest DA2-receptors are involved in the control of small intestinal transit time in rats. Pharmacol Res26:179-85 (1992).
Read more (PubMed: 1409258) »