製品の概要

  • 製品名(S)-5-Nitrowillardiine
  • 製品の詳細
    AMPA / kainate agonist
  • 生理活性の詳細Broad spectrum agonist for AMPA and kainate receptors with no activity at NMDA or metabotropic receptors
  • 精製度> 98%

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab120063 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    (S)-5-Nitrowillardiine 画像

    • ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with (S)-5-Nitrowillardiine (ab120063), by ICC/IF. Increase in MEK1 (phospho S298) expression correlates with increased concentration of (S)-5-Nitrowillardiine, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120063 ((S)-5-Nitrowillardiine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    (S)-5-Nitrowillardiine (ab120063) 使用論文

    This product has been referenced in:
    • Jane DE  et al. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem 40:3645-50 (1997). Read more (PubMed: 9357531) »
    • Wong LA  et al. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J Neurosci 14:3881-97 (1994). Read more (PubMed: 7515954) »

    See 1 Publication for this product

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    Thank you for contacting Abcam regarding ab120063 (Asc-063).


    I have had a quick look at the literature and haven't found any information regarding UV absorption of Nitrowillardiine.


    We have a UV absorbance spectrum, obta...

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