製品の概要

  • 製品名
    S 24795
  • 製品の詳細
    Partial α7 nAChR agonist
  • 生理活性の詳細
    Partial α7 nAChR agonist (EC50 = 34 μM). Alleviates memory impairments, improving contextual memory. Displays greater memory enhancement effect than Memantine (ab120249). Disrupts Amyloid β/ α7 nAChR interaction to reduce Alzheimer's disease-like pathologies.
  • 精製度
    > 99%

製品の特性

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参考文献

This product has been referenced in:
  • Wang HY  et al. Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J Neurosci 29:10961-73 (2009). Read more (PubMed: 19726654) »
  • Beracochea D  et al. Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology (Berl) 196:555-64 (2008). Read more (PubMed: 18034231) »
  • Lopez-Hernandez G  et al. Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons. Neuropharmacology 53:134-44 (2007). Read more (PubMed: 17544457) »

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