機能Enhances the sumoylation of a number of proteins including HIF1A, PIAS and I-kappa-B, through direct interaction with UBC9. Has no effect on ubiquitination.
組織特異性Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes.
配列類似性Contains 1 RWD domain.
ドメインThe RWD domain is required for the sumoylation enhancement activity.
細胞内局在Nucleus. Cytoplasm. Colocalizes with UBC9/UBE2I in nuclear spots.