Anti-RUNX2 抗体 [3F5] (ab110102)


  • 製品名Anti-RUNX2 antibody [3F5]
    RUNX2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3F5] to RUNX2
  • アプリケーション適用あり: WB, IHC-P, ICC/IF, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 251-351 of Human RUNX2 with a proprietary tag (NP_004339)

  • ポジティブ・コントロール
    • Uterus or prostate Human tissue. HeLa cells. PC-12 cell lysate.



Our Abpromise guarantee covers the use of ab110102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 10 µg/ml.
Sandwich ELISA Use at an assay dependent concentration.


  • 機能Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
  • 組織特異性Specifically expressed in osteoblasts.
  • 関連疾患Defects in RUNX2 are the cause of cleidocranial dysplasia (CLCD) [MIM:119600]; also known as cleidocranial dysostosis (CCD). CLCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies.
  • 配列類似性Contains 1 Runt domain.
  • ドメインA proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.
  • 翻訳後修飾Phosphorylated; probably by MAP kinases (MAPK) (By similarity). Isoform 3 is phosphorylated on Ser-340.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Acute myeloid leukemia 3 protein antibody
    • Alpha subunit 1 antibody
    • AML3 antibody
    • CBF alpha 1 antibody
    • CBF-alpha-1 antibody
    • CBFA1 antibody
    • CCD antibody
    • CCD1 antibody
    • Cleidocranial dysplasia 1 antibody
    • Core binding factor antibody
    • Core binding factor runt domain alpha subunit 1 antibody
    • Core binding factor subunit alpha 1 antibody
    • Core-binding factor subunit alpha-1 antibody
    • MGC120022 antibody
    • MGC120023 antibody
    • Oncogene AML 3 antibody
    • Oncogene AML-3 antibody
    • OSF 2 antibody
    • OSF-2 antibody
    • OSF2 antibody
    • Osteoblast specific transcription factor 2 antibody
    • Osteoblast-specific transcription factor 2 antibody
    • OTTHUMP00000016533 antibody
    • PEA2 alpha A antibody
    • PEA2-alpha A antibody
    • PEA2aA antibody
    • PEBP2 alpha A antibody
    • PEBP2-alpha A antibody
    • PEBP2A1 antibody
    • PEBP2A2 antibody
    • PEBP2aA antibody
    • PEBP2aA1 antibody
    • Polyomavirus enhancer binding protein 2 alpha A subunit antibody
    • Polyomavirus enhancer-binding protein 2 alpha A subunit antibody
    • Runt domain antibody
    • Runt related transcription factor 2 antibody
    • Runt-related transcription factor 2 antibody
    • RUNX2 antibody
    • RUNX2_HUMAN antibody
    • SL3 3 enhancer factor 1 alpha A subunit antibody
    • SL3-3 enhancer factor 1 alpha A subunit antibody
    • SL3/AKV core binding factor alpha A subunit antibody
    • SL3/AKV core-binding factor alpha A subunit antibody
    see all

Anti-RUNX2 antibody [3F5] 画像

  • Anti-RUNX2 antibody [3F5] (ab110102) + PC12 cell lysate

    Predicted band size : 57 kDa
  • ab110102 at 5µg/ml staining RUNX2 in formalin/-fixed, paraffin-embedded Human prostate tissue.
  • ab110102 at 5µg/ml staining RUNX2 in formalin/-fixed, paraffin-embedded Human uterus tissue.
  • Immunofluorescence analysis of RUNX2 expression in HeLa cells using ab110102 at 10µg/ml.
  • Detection limit for recombinant ab110102 is approximately 0.1 ng/ml as a capture antibody.

Anti-RUNX2 antibody [3F5] (ab110102) 使用論文

ab110102 has not yet been referenced specifically in any publications.

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Thank you for contacting us. Tha Anti-RUNX2 antibody [3F5] (ab110102) was tested for western blotting with denatured, reduced samples. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or ...

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